Pub. Date : 2006 Aug
PMID : 16847337
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. | Sphingolipids | KH RNA binding domain containing, signal transduction associated 2 | Homo sapiens |
| 2 | Consistent with these data, we show that the previously characterized phosphoinositide effectors, Slm1 and Slm2, which regulate actin organization, are also necessary for normal sphingolipid metabolism, at least in part through regulation of the calcium/calmodulin-dependent phosphatase calcineurin, which binds directly to both proteins. | Sphingolipids | KH RNA binding domain containing, signal transduction associated 2 | Homo sapiens |
| 3 | Together, our data suggest that Slm1 and Slm2 define a molecular link between phosphoinositide and sphingolipid signaling and thereby regulate actin cytoskeleton organization. | Sphingolipids | KH RNA binding domain containing, signal transduction associated 2 | Homo sapiens |