Title : Taurine chloramine inhibits PMA-stimulated superoxide production in human neutrophils perhaps by inhibiting phosphorylation and translocation of p47(phox).

Pub. Date : 2006 Sep

PMID : 16846837






2 Functional Relationships(s)
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1 These results suggest that Tau-Cl inhibits PMA-elicited O(2)(-) production in PLB-985 granulocytes by inhibiting phosphorylation of p47(phox) and translocation of p47(phox) and p67(phox), eventually blocking the assembly of NADPH oxidase complex. Tetradecanoylphorbol Acetate CD33 molecule Homo sapiens
2 Translocation of p47(phox), p67(phox) and Rac was increased in response to PMA, and Tau-Cl inhibited the PMA-stimulated translocation of p47(phox) and p67(phox) to plasma membrane without affecting the translocation of Rac. Tetradecanoylphorbol Acetate CD33 molecule Homo sapiens