Title : Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium.

Pub. Date : 2006 Jun

PMID : 16846546






3 Functional Relationships(s)
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1 RESULTS: Ketorolac was six times more active against COX-1 (IC(50) = 0.02 microM) than COX-2 (IC(50) = 0.12 microM) while bromfenac was approximately 32 times more active against COX-2 (IC(50) = 0.0066 microM) than COX-1 (IC(50) = 0.210 microM). Ketorolac cytochrome c oxidase subunit I Oryctolagus cuniculus
2 RESULTS: Ketorolac was six times more active against COX-1 (IC(50) = 0.02 microM) than COX-2 (IC(50) = 0.12 microM) while bromfenac was approximately 32 times more active against COX-2 (IC(50) = 0.0066 microM) than COX-1 (IC(50) = 0.210 microM). Ketorolac cytochrome c oxidase subunit I Oryctolagus cuniculus
3 CONCLUSIONS: Ketorolac is relatively COX-1 selective while bromfenac is potently selective for COX-2 over COX-1. Ketorolac cytochrome c oxidase subunit I Oryctolagus cuniculus