Title : 4-hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells.

Pub. Date : 2006 Oct 15

PMID : 16843508






2 Functional Relationships(s)
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1 The GSH homeostasis was affected as both mitochondrial and extramitochondrial GSH levels, GSH peroxidase and glutathione reductase activities were inhibited and glutathione S-transferase (GST) activity was increased after 4-HNE treatment. Glutathione hematopoietic prostaglandin D synthase Rattus norvegicus
2 The GSH homeostasis was affected as both mitochondrial and extramitochondrial GSH levels, GSH peroxidase and glutathione reductase activities were inhibited and glutathione S-transferase (GST) activity was increased after 4-HNE treatment. Glutathione hematopoietic prostaglandin D synthase Rattus norvegicus