Pub. Date : 2006 Oct
PMID : 16837557
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic nicotine treatment led to a small decrease in alpha3/alpha6beta2* nAChR subtypes. | Nicotine | immunoglobulin kappa variable 2D-28 | Homo sapiens |
| 2 | The decline in alpha3/alpha6beta2* subtypes, defined using alpha-conotoxinMII-sensitive (125)I-epibatidine or [(125)I]A85380 binding, was significantly smaller in striatum of nicotine-treated lesioned monkeys compared with unlesioned monkeys. | Nicotine | immunoglobulin kappa variable 2D-28 | Homo sapiens |
| 3 | These data suggest that there are at least two striatal alpha3/alpha6beta2* subtypes that are differentially affected by chronic nicotine treatment in lesioned animals. | Nicotine | immunoglobulin kappa variable 2D-28 | Homo sapiens |
| 4 | In addition, the results showing an improvement in striatal alpha4beta2* and select alpha3/alpha6beta2* nAChR subtypes, combined with previous work, demonstrate that chronic nicotine treatment restores and/or protects against the loss of multiple molecular markers after nigrostriatal damage. | Nicotine | immunoglobulin kappa variable 2D-28 | Homo sapiens |