Pub. Date : 2006 Oct
PMID : 16837501
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thalidomide reduces IL-18, IL-8 and TNF-alpha release from alveolar macrophages in interstitial lung disease. | Thalidomide | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | At the highest thalidomide concentration (0.1 mM), LPS-stimulated IL-8 production was also suppressed. | Thalidomide | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | In IPF patients, although spontaneous production of TNF-alpha, IL-12p40, IL-18 and IL-8 was lower than in sarcoidosis and HP patients, with LPS stimulation the cytokines were significantly elevated and also partially inhibited by thalidomide. | Thalidomide | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | In conclusion, thalidomide has the potential to improve the therapeutic regimens for sarcoidosis, hypersensitivity pneumonitis and idiopathic pulmonary fibrosis by reducing tumour necrosis factor-alpha, interleukin-12p40, interleukin-18 and interleukin-8 production. | Thalidomide | C-X-C motif chemokine ligand 8 | Homo sapiens |