Title : Bezafibrate induces FALDH in human fibroblasts; implications for Sjögren-Larsson syndrome.

Pub. Date : 2006 Sep-Oct

PMID : 16837225






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Our results show that FALDH activity was induced 1.4-fold after a 3-day treatment with 800 microM bezafibrate in fibroblasts of control subjects. Bezafibrate aldehyde dehydrogenase 3 family member A2 Homo sapiens
2 Interestingly, in fibroblasts of two SLS patients homozygous for the p.R228C substitution, FALDH activity could be induced to 37% of control values by bezafibrate treatment. Bezafibrate aldehyde dehydrogenase 3 family member A2 Homo sapiens
3 mRNA analysis in fibroblasts of these patients also revealed a mean 1.8-fold induction of FALDH mRNA after bezafibrate treatment. Bezafibrate aldehyde dehydrogenase 3 family member A2 Homo sapiens