Title : C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans.

Pub. Date : 2006 Aug 15

PMID : 16828468






1 Functional Relationships(s)
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1 We hypothesize that HSPGs are necessary for pharyngeal isthmus elongation, and pyr-1 functions upstream of proteoglycan synthesizing enzymes by providing precursors of UDP-sugars essential for HSPG synthesis. Uridine Diphosphate Sugars Glutamine-dependent carbamoyl-phosphate synthase Caenorhabditis elegans