Pub. Date : 2007 Mar
PMID : 16821082
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers. | Docetaxel | YKT6 v-SNARE homolog | Homo sapiens |
| 2 | Of these 13 genes, mRNA expression of CCT5, RGS3, and YKT6 was significantly up-regulated in p53-mutated tumors and associated with a low response rate to docetaxel. | Docetaxel | YKT6 v-SNARE homolog | Homo sapiens |
| 3 | Treatment of MCF-7 cells with siRNA specific for CCT5, RGS3, or YKT6 resulted in a significant enhancement of docetaxel-induced apoptosis. | Docetaxel | YKT6 v-SNARE homolog | Homo sapiens |
| 4 | CONCLUSIONS: CCT5, RGS3, and YKT6 mRNA expressions, which are up-regulated in p53-mutated breast tumors, might be implicated in resistance to docetaxel and clinically useful in identifying the subset of breast cancer patients who may or may not benefit from docetaxel treatment. | Docetaxel | YKT6 v-SNARE homolog | Homo sapiens |
| 5 | CONCLUSIONS: CCT5, RGS3, and YKT6 mRNA expressions, which are up-regulated in p53-mutated breast tumors, might be implicated in resistance to docetaxel and clinically useful in identifying the subset of breast cancer patients who may or may not benefit from docetaxel treatment. | Docetaxel | YKT6 v-SNARE homolog | Homo sapiens |