Title : Increased protein glycation in fructosamine 3-kinase-deficient mice.

Pub. Date : 2006 Oct 15

PMID : 16819943






6 Functional Relationships(s)
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1 The urinary excretion of free fructose-epsilon-lysine was 10-20-fold higher in fed mice compared with mice starved for 36 h, and did not differ between fed Fn3k+/+ and Fn3k-/- mice, indicating that food is the main source of urinary fructose-epsilon-lysine in these mice and that FN3K does not participate in the metabolism of food-derived fructose-epsilon-lysine. fructose-epsilon-lysine fructosamine 3 kinase Mus musculus
2 However, in starved animals, the urinary excretion of fructose-epsilon-lysine was 2.5-fold higher in Fn3k-/- mice compared with Fn3k+/+ or Fn3k+/- mice. fructose-epsilon-lysine fructosamine 3 kinase Mus musculus
3 Furthermore, a marked increase (5-13-fold) was observed in the concentration of free fructose-epsilon-lysine in tissues of fed Fn3k-/- mice compared with control mice, indicating that FN3K participates in the metabolism of endogenously produced fructose-epsilon-lysine. fructose-epsilon-lysine fructosamine 3 kinase Mus musculus
4 Furthermore, a marked increase (5-13-fold) was observed in the concentration of free fructose-epsilon-lysine in tissues of fed Fn3k-/- mice compared with control mice, indicating that FN3K participates in the metabolism of endogenously produced fructose-epsilon-lysine. fructose-epsilon-lysine fructosamine 3 kinase Mus musculus
5 Furthermore, a marked increase (5-13-fold) was observed in the concentration of free fructose-epsilon-lysine in tissues of fed Fn3k-/- mice compared with control mice, indicating that FN3K participates in the metabolism of endogenously produced fructose-epsilon-lysine. fructose-epsilon-lysine fructosamine 3 kinase Mus musculus
6 Taken together, these data indicate that FN3K serves as a protein repair enzyme and also in the metabolism of endogenously produced free fructose-epsilon-lysine. fructose-epsilon-lysine fructosamine 3 kinase Mus musculus