Title : Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant.

Pub. Date : 2006 Jul

PMID : 16817855






1 Functional Relationships(s)
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1 We recently reported that the transient expression of polyglutamine tracts of various size in exon 1 of the huntingtin polypeptide (httEx1) generated abnormally high levels of intracellular reactive oxygen species that directly contributed to cell death. Reactive Oxygen Species huntingtin Homo sapiens