Title : Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms.

Pub. Date : 2006 Aug 14

PMID : 16814279






1 Functional Relationships(s)
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1 Nimesulide or indomethacin administered i.p 30 min prior LPS, IL-1beta, IL-6, TNF-alpha or arachidonic acid reduced the febrile response and PGE(2) or PGF(2alpha) levels in LPS-febrile rats but did not modify PGE(2)-induced fever. Prostaglandins E interleukin 1 beta Rattus norvegicus