Pub. Date : 1991 Aug
PMID : 1681068
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the presence of AAG the EC50 value of phenylephrine at 5.69 nM unbound prazosin was on average 47% lower than in the absence of AAG (P less than 0.002), at 122 nM unbound tiodazosin, 39% lower (P less than 0.01), and at 25.6 nM unbound WB4101, 68% lower (P less than 0.002). | Prazosin | alpha-1-acid glycoprotein | Oryctolagus cuniculus |
| 2 | The effect of AAG on the antagonistic activity of prazosin was concentration-dependent with a maximum suppression of prazosin activity of 79% and with a half-maximum concentration of 1.1 microM AAG. | Prazosin | alpha-1-acid glycoprotein | Oryctolagus cuniculus |
| 3 | The effect of AAG on the antagonistic activity of prazosin was concentration-dependent with a maximum suppression of prazosin activity of 79% and with a half-maximum concentration of 1.1 microM AAG. | Prazosin | alpha-1-acid glycoprotein | Oryctolagus cuniculus |
| 4 | The effect of AAG on the antagonistic activity of prazosin was concentration-dependent with a maximum suppression of prazosin activity of 79% and with a half-maximum concentration of 1.1 microM AAG. | Prazosin | alpha-1-acid glycoprotein | Oryctolagus cuniculus |
| 5 | AAG significantly decreased prazosin"s ability to reduce alpha 1-adrenergic stimulation of calcium influx (P less than 0.05), while it had no effect on prazosin"s ability to decrease alpha 1-adrenergic-stimulated formation of inositol phosphate. | Prazosin | alpha-1-acid glycoprotein | Oryctolagus cuniculus |