Title : Detection of muramyl dipeptide-sensing pathway defects in patients with Crohn's disease.

Pub. Date : 2006 Jul

PMID : 16804397






2 Functional Relationships(s)
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1 RESULTS: The assay was highly sensitive and specific for detection of profound defects in muramyl dipeptide sensing caused by double NOD2 mutations (IL-8 P = 0.0002; IL-1beta P = 0.0002). Dipeptides C-X-C motif chemokine ligand 8 Homo sapiens
2 Healthy NOD2 heterozygotes had modest impairment of muramyl dipeptide induced IL-8 secretion (P = 0.003). Dipeptides C-X-C motif chemokine ligand 8 Homo sapiens