Title : Differential expression of p73 isoforms in relation to drug resistance in childhood T-lineage acute lymphoblastic leukaemia.

Pub. Date : 2006 Aug

PMID : 16791269






2 Functional Relationships(s)
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1 Leukaemic cells of T-ALL patients expressing higher levels of antiapoptotic p73 were more resistant to the DNA-damaging drug daunorubicin compared to cells of patients with low or negative expression or these isoforms (P(trend)=0.045). Daunorubicin tumor protein p73 Homo sapiens
2 Interestingly, p73Deltaex2 was the most abundantly expressed antiapoptotic isoform in daunorubicin-resistant patient cells (44% of total p73). Daunorubicin tumor protein p73 Homo sapiens