Title : Berberine potently inhibits protein tyrosine phosphatase 1B: investigation by docking simulation and experimental validation.

Pub. Date : 2006 Apr

PMID : 16789430






1 Functional Relationships(s)
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1 Berberine was found to readily fit within the binding pocket of h-PTP 1B in a low energy orientation characterized with optimal electrostatic attractive interactions bridging the isoquinolinium positively charged nitrogen atom of berberine and the negatively charged acidic residue of ASP 48 of h-PTP 1B. Aspartic Acid protein tyrosine phosphatase non-receptor type 1 Homo sapiens