Pub. Date : 2006
PMID : 16788306
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The NK1 receptor antagonist SR140333 inhibits capsaicin-induced ERK phosphorylation in sensory neurons. | Capsaicin | Eph receptor B1 | Rattus norvegicus |
| 2 | Capsaicin evoked a threefold increase in phospho-ERK in the sciatic nerve and a two- to threefold increase in the DRG at 3 h and 6 h after the treatment. | Capsaicin | Eph receptor B1 | Rattus norvegicus |
| 3 | SR140333 markedly attenuated the capsaicin-induced increase in phosphorylated ERK. | Capsaicin | Eph receptor B1 | Rattus norvegicus |
| 4 | Based on the present results and previous findings it can be postulated that the capsaicin-induced ERK phosphorylation in sensory neurons is not a direct effect by capsaicin, but that rather substance P release from the stimulated sensory neurons with an NK1-mediated nerve growth factor (NGF) production is involved. | Capsaicin | Eph receptor B1 | Rattus norvegicus |