Title : Reduced tyrosine hydroxylase and GTP cyclohydrolase mRNA expression, tyrosine hydroxylase activity, and associated neurochemical alterations in Nurr1-null heterozygous mice.

Pub. Date : 2006 Jun 30

PMID : 16782508






5 Functional Relationships(s)
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1 The nuclear receptor Nurr1 is essential for the development of midbrain dopamine neurons and appears to be an important regulator of dopamine levels as adult Nurr1-null heterozygous (+/-) mice have reduced mesolimbic/mesocortical dopamine levels. Dopamine nuclear receptor subfamily 4, group A, member 2 Mus musculus
2 The nuclear receptor Nurr1 is essential for the development of midbrain dopamine neurons and appears to be an important regulator of dopamine levels as adult Nurr1-null heterozygous (+/-) mice have reduced mesolimbic/mesocortical dopamine levels. Dopamine nuclear receptor subfamily 4, group A, member 2 Mus musculus
3 The nuclear receptor Nurr1 is essential for the development of midbrain dopamine neurons and appears to be an important regulator of dopamine levels as adult Nurr1-null heterozygous (+/-) mice have reduced mesolimbic/mesocortical dopamine levels. Dopamine nuclear receptor subfamily 4, group A, member 2 Mus musculus
4 The mechanism(s) through which reduced Nurr1 expression affects dopamine levels has not been determined. Dopamine nuclear receptor subfamily 4, group A, member 2 Mus musculus
5 Together, these data suggest that Nurr1 may function to modify TH and GTPCH expression and dopamine synthesis. Dopamine nuclear receptor subfamily 4, group A, member 2 Mus musculus