Title : ZD7288 inhibits exocytosis in an HCN-independent manner and downstream of voltage-gated calcium influx in pituitary lactotrophs.

Pub. Date : 2006 Aug 4

PMID : 16780797






2 Functional Relationships(s)
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1 Pituitary lactotrophs fire action potentials spontaneously and the associated voltage-gated calcium influx is sufficient to maintain high prolactin release. Calcium prolactin Homo sapiens
2 Agonist and Bay K 8644-stimulated prolactin release was also inhibited by ZD7288, indicating that this compound attenuates the exocytotic pathway downstream of calcium influx. Calcium prolactin Homo sapiens