Pub. Date : 1991 Jul
PMID : 1677450
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present in vitro study, the formation in human T cells (MOLT-4, ATH8, and CCRF-CEM) of the pharmacologically active metabolite of ddIno and ddAdo, 2",3"-dideoxyadenosine-5"-triphosphate (ddATP), was found to be stimulated 2-4-fold by appropriate concentrations of inosinate dehydrogenase (IMPD) inhibitors such as ribavirin, tiazofurin, and mycophenolic acid. | Didanosine | inosine monophosphate dehydrogenase 1 | Homo sapiens |
| 2 | No change was noted in the intracellular concentration of the corresponding physiological deoxynucleoside-5"-triphosphate, dATP; positive correlation was observed, however, between the increase in ddATP formation from ddIno and the increase in intracellular IMP occurring as a consequence of IMPD inhibition. | Didanosine | inosine monophosphate dehydrogenase 1 | Homo sapiens |
| 3 | The results support the hypothesis that the stimulation of ddATP formation seen when ddIno is combined with ribavirin or other IMPD inhibitors is a consequence of an increased concentration of IMP, the major phosphate donor for the initial phosphorylation step in the anabolism of ddIno to ddATP, i.e., ddIno----ddIMP. | Didanosine | inosine monophosphate dehydrogenase 1 | Homo sapiens |