Pub. Date : 2006 Aug 4
PMID : 16762923
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1. | Superoxides | NADPH oxidase 1 | Homo sapiens |
| 2 | Activation of the non-phagocytic superoxide-producing NADPH oxidase Nox1, complexed with p22(phox) at the membrane, requires its regulatory soluble proteins Noxo1 and Noxa1. | Superoxides | NADPH oxidase 1 | Homo sapiens |
| 3 | Electropermeabilized HeLa cells, ectopically expressing Nox1, Noxo1, and Noxa1, produce superoxide in a GTP-dependent manner, which is abrogated by expression of a mutant Noxa1(R103E), defective in Rac binding. | Superoxides | NADPH oxidase 1 | Homo sapiens |
| 4 | Superoxide production in Nox1-expressing HeLa and Caco-2 cells is decreased by depletion or sequestration of Rac; on the other hand, it is enhanced by expression of the constitutively active Rac1(Q61L), but not by that of a mutant Rac1 with the A27K substitution, deficient in binding to Noxa1. | Superoxides | NADPH oxidase 1 | Homo sapiens |