Title : [Enhanced cisplatin cytotoxicity by RNA interfering the excision repair cross-complementing 1 gene in ovarian cancer cell lines].

Pub. Date : 2006 May

PMID : 16762192






3 Functional Relationships(s)
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1 OBJECTIVE: To study changes of cisplatin sensitivity by RNA interfering the excision repair cross-complementing (ERCC) 1 gene in ovarian cancer cell lines. Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
2 The sensitivity to cisplatin of ES-2 cell line was increased by 53.88 times after disturbing the ERCC1 gene. Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
3 CONCLUSION: The sensitivity to cisplatin of ovarian cancer cell lines ES-2 could be enhanced by RNA interfering ERCC1 gene. Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens