Title : Strand specificity for UV-induced DNA repair and mutations in the Chinese hamster HPRT gene.

Pub. Date : 1991 May 11

PMID : 1674998






1 Functional Relationships(s)
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1 In 23 hprt mutants from V79 Chinese hamster cells induced by 2 J/m2 UV we found a strong strand bias for mutation induction: assuming that pre-mutagenic lesions occur at dipyrimidine sequences, 85% of the mutations could be attributed to lesions in the nontranscribed strand. dipyrimidine hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus