Pub. Date : 2006 Jun 1
PMID : 16740726
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5. | Glycosides | TNF receptor superfamily member 10a | Homo sapiens |
| 2 | Blocking of up-regulation of DR4 and DR5 alone significantly reduced cell death after combined treatment with cardiac glycosides and Apo2L/TRAIL. | Glycosides | TNF receptor superfamily member 10a | Homo sapiens |
| 3 | Combined silencing of DR4 and DR5 abrogated the ability of cardiac glycosides and Apo2L/TRAIL to induce apoptosis in an additive manner. | Glycosides | TNF receptor superfamily member 10a | Homo sapiens |
| 4 | To our knowledge, this is the first demonstration that glycosides up-regulate DR4 and DR5, thereby reverting the resistance of lung cancer cells to Apo2/TRAIL-induced apoptosis. | Glycosides | TNF receptor superfamily member 10a | Homo sapiens |
| 5 | To our knowledge, this is the first demonstration that glycosides up-regulate DR4 and DR5, thereby reverting the resistance of lung cancer cells to Apo2/TRAIL-induced apoptosis. | Glycosides | TNF receptor superfamily member 10a | Homo sapiens |