Title : Ciliary neurotrophic factor activates astrocytes, redistributes their glutamate transporters GLAST and GLT-1 to raft microdomains, and improves glutamate handling in vivo.

Pub. Date : 2006 May 31

PMID : 16738240






3 Functional Relationships(s)
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1 Using microdialysis in the rat striatum, we found that the accumulation of extracellular glutamate induced by quinolinate (QA) was reduced threefold with CNTF. Quinolinic Acid ciliary neurotrophic factor Rattus norvegicus
2 Using microdialysis in the rat striatum, we found that the accumulation of extracellular glutamate induced by quinolinate (QA) was reduced threefold with CNTF. Quinolinic Acid ciliary neurotrophic factor Rattus norvegicus
3 In line with this result, CNTF significantly increased QA-induced [(18)F]-fluoro-2-deoxyglucose uptake, an indirect index of glutamate uptake by astrocytes. Quinolinic Acid ciliary neurotrophic factor Rattus norvegicus