Pub. Date : 2006 Aug
PMID : 16737952
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A key determinant of ARF6 function is the lifetime of the GTP-bound active state, which is orchestrated by GTPase-activating protein (GAP) and GTP-GDP exchanging factor. | Guanosine Triphosphate | ADP ribosylation factor 6 | Homo sapiens |
| 2 | A key determinant of ARF6 function is the lifetime of the GTP-bound active state, which is orchestrated by GTPase-activating protein (GAP) and GTP-GDP exchanging factor. | Guanosine Triphosphate | ADP ribosylation factor 6 | Homo sapiens |
| 3 | Expression of GTP hydrolysis-resistant ARF6(Q67L) resulted in accumulations of ACAP4 and ARF6 in the cytoplasmic membrane, suggesting that GTP hydrolysis is required for the ARF6-dependent membrane remodeling. | Guanosine Triphosphate | ADP ribosylation factor 6 | Homo sapiens |
| 4 | Expression of GTP hydrolysis-resistant ARF6(Q67L) resulted in accumulations of ACAP4 and ARF6 in the cytoplasmic membrane, suggesting that GTP hydrolysis is required for the ARF6-dependent membrane remodeling. | Guanosine Triphosphate | ADP ribosylation factor 6 | Homo sapiens |
| 5 | Expression of GTP hydrolysis-resistant ARF6(Q67L) resulted in accumulations of ACAP4 and ARF6 in the cytoplasmic membrane, suggesting that GTP hydrolysis is required for the ARF6-dependent membrane remodeling. | Guanosine Triphosphate | ADP ribosylation factor 6 | Homo sapiens |
| 6 | Expression of GTP hydrolysis-resistant ARF6(Q67L) resulted in accumulations of ACAP4 and ARF6 in the cytoplasmic membrane, suggesting that GTP hydrolysis is required for the ARF6-dependent membrane remodeling. | Guanosine Triphosphate | ADP ribosylation factor 6 | Homo sapiens |
| 7 | Expression of GTP hydrolysis-resistant ARF6(Q67L) resulted in accumulations of ACAP4 and ARF6 in the cytoplasmic membrane, suggesting that GTP hydrolysis is required for the ARF6-dependent membrane remodeling. | Guanosine Triphosphate | ADP ribosylation factor 6 | Homo sapiens |
| 8 | Expression of GTP hydrolysis-resistant ARF6(Q67L) resulted in accumulations of ACAP4 and ARF6 in the cytoplasmic membrane, suggesting that GTP hydrolysis is required for the ARF6-dependent membrane remodeling. | Guanosine Triphosphate | ADP ribosylation factor 6 | Homo sapiens |
| 9 | Significantly the depletion of ACAP4 by small interfering RNA or inhibition of ARF6 GTP hydrolysis by overexpressing GAP-deficient ACAP4 suppressed ARF6-dependent cell migration in wound healing, demonstrating the importance of ACAP4 in cell migration. | Guanosine Triphosphate | ADP ribosylation factor 6 | Homo sapiens |
| 10 | Significantly the depletion of ACAP4 by small interfering RNA or inhibition of ARF6 GTP hydrolysis by overexpressing GAP-deficient ACAP4 suppressed ARF6-dependent cell migration in wound healing, demonstrating the importance of ACAP4 in cell migration. | Guanosine Triphosphate | ADP ribosylation factor 6 | Homo sapiens |