Title : Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet.

Pub. Date : 2006 Jun

PMID : 16732014






3 Functional Relationships(s)
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1 However, in women we found statistically significant gene-diet interactions (recessive model) between PLIN 11482G-->A/14995A-->T polymorphisms (in high linkage disequilibrium) and saturated fatty acids (SFAs; P = 0.003/0.005) and carbohydrate (P = 0.004/0.012) in determining HOMA-IR. Fatty Acids perilipin 1 Homo sapiens
2 Thus, women in the highest SFA tertile (11.8-19%) had higher HOMA-IR (48% increase; P trend = 0.006) than women in the lowest (3.1-9.4%) only if they were homozygotes for the PLIN minor allele. Fatty Acids perilipin 1 Homo sapiens
3 CONCLUSIONS: PLIN 11482G-->A/14995A-->T polymorphisms modulate the association between SFAs/carbohydrate in diet and insulin resistance in Asian women. Fatty Acids perilipin 1 Homo sapiens