Title : Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis.

Pub. Date : 2006 May 24

PMID : 16723520






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In cultures treated with TNFalpha (100 ng/ml), the oligodendrocyte survival rate was 18% compared with cultures treated with TNFalpha and rhgas6 (64%) or the caspase inhibitors IETD-fmk [z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethyl ketone] (65%) and zVAD-fmk (N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone) (63%). benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone tumor necrosis factor Homo sapiens