Title : Synthesis and biological evaluation of cyclopropyl analogues of 2-amino-5-phosphonopentanoic acid.

Pub. Date : 1991 Jan

PMID : 1671413






1 Functional Relationships(s)
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1 Of the compounds tested, 4,5-methano-AP5 analogue 26 was the most potent selective NMDA antagonist; however, potency was lower than that for [[(+/-)-2-carboxypiperidin-4-yl]methyl]phosphonic acid (CGS 19755, 5). N-Methylaspartate adaptor related protein complex 5 subunit beta 1 Homo sapiens