Title : Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axis.

Pub. Date : 2006 Dec

PMID : 16710317






2 Functional Relationships(s)
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1 Furthermore, chronic desipramine treatment resulted in a reduction in both secretion of corticosterone and the induction of the immediate early gene c-fos in the medial dorsal parvocellular region of the paraventricular nucleus of the hypothalamus (PVN) following a 5 min exposure to swim stress. Desipramine Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Acute treatment with the CB(1) receptor antagonist, AM251 (1 mg/kg), before exposure to swim stress, completely occluded the ability of desipramine to reduce both corticosterone secretion and induction of c-fos expression in the PVN. Desipramine Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens