Title : Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: A basis for the design of specific inhibitors.

Pub. Date : 2006 May

PMID : 16698551






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Dimethylarginine dimethylaminohydrolase (DDAH) is involved in the regulation of nitric oxide synthase (NOS) by metabolizing the free endogenous arginine derivatives N(omega)-methyl-L-arginine (MMA) and N(omega),N(omega)-dimethyl-L-arginine (ADMA), which are competitive inhibitors of NOS. omega-N-Methylarginine dimethylarginine dimethylaminohydrolase 1 Homo sapiens