Title : 4-(Oxoalkyl)-substituted GABA analogues as inactivators and substrates of GABA aminotransferase.

Pub. Date : 1991

PMID : 1669447






1 Functional Relationships(s)
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1 On the basis of the mechanism of inactivation of gamma-aminobutyric acid (GABA) aminotransferase by gamma-ethynyl GABA that was reported recently (Burke and Silverman, manuscript submitted), three 4-(oxoalkyl)-substituted GABA analogues, 4-amino-5-oxohexanoic acid (7), 4-amino-5-oxopentanoic acid (8), and 4-amino-6-oxohexanoic acid (9) were synthesized and tested as inactivators. DTXSID90568301 4-aminobutyrate aminotransferase Homo sapiens