Pub. Date : 2006 Aug
PMID : 16687390
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. | Polycyclic Aromatic Hydrocarbons | aryl hydrocarbon receptor 1a | Danio rerio |
| 2 | Another class of AHR agonists of increasing concern because of their known toxicity and ubiquity in the environment is the polycyclic aromatic hydrocarbons (PAHs). | Polycyclic Aromatic Hydrocarbons | aryl hydrocarbon receptor 1a | Danio rerio |
| 3 | Another class of AHR agonists of increasing concern because of their known toxicity and ubiquity in the environment is the polycyclic aromatic hydrocarbons (PAHs). | Polycyclic Aromatic Hydrocarbons | aryl hydrocarbon receptor 1a | Danio rerio |
| 4 | As observed in previous studies with killifish (Fundulus heteroclitus), we demonstrate here that coexposure of zebrafish (Danio rerio) embryos to the PAH-type AHR agonist beta-naphthoflavone (BNF) and the CYP1A inhibitor alpha-naphthoflavone (ANF) significantly enhanced toxicity above that observed for single-compound exposures. | Polycyclic Aromatic Hydrocarbons | aryl hydrocarbon receptor 1a | Danio rerio |
| 5 | In order to elucidate the role of the AHR pathway in mediating synergistic toxicity of PAH mixtures to early life stages, we used a morpholino approach to knock down expression of zebrafish AHR2 and CYP1A proteins during development. | Polycyclic Aromatic Hydrocarbons | aryl hydrocarbon receptor 1a | Danio rerio |