Title : Tryptophan protects human melanoma cells against gamma-interferon and tumour necrosis factor-alpha: a unifying mechanism of action.

Pub. Date : 1991 Aug-Sep

PMID : 1668725






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 TNF-alpha induces manganese-containing superoxide dismutase (MnSOD) which also uses O2- to produce cytotoxic concentrations of hydrogen peroxide. Superoxides tumor necrosis factor Homo sapiens
2 Therefore, it can be concluded that the cytotoxicity of both gamma-IFN and TNF-alpha depends on the availability of L-tryptophan as the substrate for the removal of O2- via indoleamine 2,3-dioxygenase. Superoxides tumor necrosis factor Homo sapiens