Title : Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase.

Pub. Date : 2006 Jul 15

PMID : 16678413






1 Functional Relationships(s)
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1 Modifications at the 3 position of the pyridine ring led to a number of potent compounds with improved physical properties, resulting in the identification of 11g as a promising, orally active Akt inhibitor. pyridine AKT serine/threonine kinase 1 Homo sapiens