Pub. Date : 2006 May 15
PMID : 16670331
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MD-2 directly interacts with LPS, and the region from Phe(119) to Lys(132) (Arg(132) in mice) has been shown to be important for interaction between LPS and TLR4/MD-2. | Phenylalanine | lymphocyte antigen 96 | Mus musculus |
| 2 | MD-2 mutants substituting alanine for Phe(126) or Gly(129) impaired LPS-induced TLR4 clustering, but not LPS binding to TLR4/MD-2, demonstrating that ligand-induced receptor clustering is differentially regulated by MD-2 from ligand binding. | Phenylalanine | lymphocyte antigen 96 | Mus musculus |