Title : Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport.

Pub. Date : 2006 Jun 23

PMID : 16644736






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PKC-zeta in L6 myotubes and PKC-lambda in 3T3/L1 adipocytes, that nevertheless can function interchangeably for glucose transport. Glucose protein kinase C zeta Homo sapiens
2 Accordingly, in L6 myotubes, RNAi-targeting PKC-zeta, but not PKC-lambda, markedly depleted aPKC and concomitantly inhibited insulin-stimulated glucose transport; more importantly, these depleting/inhibitory effects were rescued by adenovirally mediated expression of PKC-lambda. Glucose protein kinase C zeta Homo sapiens