Pub. Date : 2006 May
PMID : 16635015
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin inhibits both ER alpha activation and breast cancer cell proliferation induced by a metalloestrogen, cadmium. | Melatonin | estrogen receptor 1 | Homo sapiens |
| 2 | The aims of this work were to test whether melatonin inhibits Cd-induced proliferation in MCF7 cells, and also to study whether melatonin specifically inhibits Cd-induced ER alpha transactivation. | Melatonin | estrogen receptor 1 | Homo sapiens |
| 3 | Melatonin is a specific inhibitor of Cd-induced ER alpha-mediated transcription in both estrogen response elements (ERE)- and AP1-containing promoters, whereas ER beta-mediated transcription is not inhibited by the pineal indole. | Melatonin | estrogen receptor 1 | Homo sapiens |
| 4 | Moreover, the mutant ER alpha-(K302G, K303G), unable to bind calmodulin, is activated by Cd but becomes insensitive to melatonin treatment. | Melatonin | estrogen receptor 1 | Homo sapiens |
| 5 | These results proved that melatonin inhibits MCF7 cell growth induced by Cd and abolishes the stimulatory effect of the heavy metal in cells expressing ER alpha at both ERE-luc and AP1-luc sites. | Melatonin | estrogen receptor 1 | Homo sapiens |