Title : 3-hydroxypyridazine 1-oxides as carboxylate bioisosteres: a new series of subtype-selective AMPA receptor agonists.

Pub. Date : 2006 Jul

PMID : 16631211






1 Functional Relationships(s)
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1 The GluR1-4 affinities of 3 were similar to 1, however, its 31-fold selectivity for GluR1/2 over GluR3/4 is the highest yet observed among azine-based glutamate analogues. pyridine glutamate ionotropic receptor AMPA type subunit 3 Rattus norvegicus