Title : 2-deoxy-D-glucose reduces the level of constitutive activation of ATM and phosphorylation of histone H2AX.

Pub. Date : 2006 Apr

PMID : 16628006






1 Functional Relationships(s)
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1 We recently reported that this constitutive H2AX phosphorylation (CHP) is markedly reduced by the antioxidant N-acetyl-L-cysteine (NAC), and postulated that it reflects the oxidative DNA damage ("endogenous DSBs") induced by reactive oxygen species (ROS) generated by metabolic activity during progression through the cell cycle. dsbs X-linked Kx blood group Homo sapiens