Title : In vivo use of the P450 inactivator 1-aminobenzotriazole in the rat: varied dosing route to elucidate gut and liver contributions to first-pass and systemic clearance.

Pub. Date : 2006 Jun

PMID : 16625658






2 Functional Relationships(s)
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1 To further study the utility of ABT, the antihistamine fexofenadine (Fex), which is not significantly metabolized and is a substrate for the uptake and efflux transporters, OATP and P-gp, was tested in rat. fexofenadine phosphoglycolate phosphatase Rattus norvegicus
2 To further study the utility of ABT, the antihistamine fexofenadine (Fex), which is not significantly metabolized and is a substrate for the uptake and efflux transporters, OATP and P-gp, was tested in rat. fexofenadine phosphoglycolate phosphatase Rattus norvegicus