Title : Neuroprotection of Tat-GluR6-9c against neuronal death induced by kainate in rat hippocampus via nuclear and non-nuclear pathways.

Pub. Date : 2006 Jun 23

PMID : 16624817






3 Functional Relationships(s)
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1 Neuroprotection of Tat-GluR6-9c against neuronal death induced by kainate in rat hippocampus via nuclear and non-nuclear pathways. Kainic Acid glutamate ionotropic receptor kainate type subunit 2 Rattus norvegicus
2 In this study, we show that kainate can enhance the assembly of the GluR6-PSD95-MLK3 module and facilitate the phosphorylation of JNK in rat hippocampal CA1 and CA3/dentate gyrus (DG) subfields. Kainic Acid glutamate ionotropic receptor kainate type subunit 2 Rattus norvegicus
3 Furthermore, kainate-induced neuronal loss in hippocampal CA1 and CA3 subregions was prevented by intracerebroventricular injection of Tat-Glur6 - 9c. Kainic Acid glutamate ionotropic receptor kainate type subunit 2 Rattus norvegicus