Title : GABA(A) receptors of hippocampal CA1 regions are involved in the acquisition and expression of morphine-induced place preference.

Pub. Date : 2007 Jan

PMID : 16624534






3 Functional Relationships(s)
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1 Intra-CA1 administration of the GABA(A) receptor agonist, muscimol (0.25, 0.5 and 1 microg/rat) significantly inhibited the morphine (5 mg/kg, s.c.)-induced CPP. Muscimol carbonic anhydrase 1 Rattus norvegicus
2 Furthermore, the muscimol-induced inhibition of morphine response was reversed by bicuculline (1 microg/rat, intra-CA1) administration. Muscimol carbonic anhydrase 1 Rattus norvegicus
3 On the other hand, the bilateral intra-CA1 injections of muscimol (0.25, 0.5 and 1 microg/rat) or bicuculline (0.5, 1 and 2 microg/rat) significantly decreased the expression of morphine-induced CPP. Muscimol carbonic anhydrase 1 Rattus norvegicus