Title : Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics.

Pub. Date : 2006 Aug 15

PMID : 16623664






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 CAR (constitutive active/androstane receptor) regulates both the distal enhancer PBREM (phenobarbital-responsive enhancer module) and the proximal element OARE [OA (okadaic acid) response element] to synergistically up-regulate the endogenous CYP2B6 (where CYP is cytochrome P450) gene in HepG2 cells. Phenobarbital cytochrome P450 family 2 subfamily B member 6 Homo sapiens
2 CAR (constitutive active/androstane receptor) regulates both the distal enhancer PBREM (phenobarbital-responsive enhancer module) and the proximal element OARE [OA (okadaic acid) response element] to synergistically up-regulate the endogenous CYP2B6 (where CYP is cytochrome P450) gene in HepG2 cells. Phenobarbital cytochrome P450 family 2 subfamily B member 6 Homo sapiens