Title : [The role of NF-E2-related factor 2 in the induction of uridine 5'-diphosphate-glucuronosyltransferase 1A and its isoforms by epigallocatechin gallate in colon cancer cells].

Pub. Date : 2006 Jan 10

PMID : 16620709






3 Functional Relationships(s)
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1 (2) The mRNA expression of Nrf2, UGT1A8, and UGT1A10 increased by 1.8-9.2 times after the addition of EGCG (all P < 0.05). epigallocatechin gallate UDP glucuronosyltransferase family 1 member A8 Homo sapiens
2 (4) The basal levels of UGT1A8 and UGT1A10 mRNA expression in the Caco-2-siNrf2 and HT-29-siNrf2 cells were lower by 15%-65% in comparison with those in control, and the induction of genes by EGCG was largely attenuated in them (all P > 0.05). epigallocatechin gallate UDP glucuronosyltransferase family 1 member A8 Homo sapiens
3 EGCG induces the expression of UGT1A, UGT1A8 and UGT1A10 genes via a Nrf2-dependent mechanism. epigallocatechin gallate UDP glucuronosyltransferase family 1 member A8 Homo sapiens