Title : Genistein suppresses proliferation and MET oncogene expression and induces EGR-1 tumor suppressor expression in immortalized human breast epithelial cells.

Pub. Date : 2006 Mar-Apr

PMID : 16619504






1 Functional Relationships(s)
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1 Treatment of the non-neoplastic, immortalized human breast epithelial MCF-10F cells with these low concentrations of genistein was associated with decreased cell proliferation, down-regulation of the protooncogene MET, up-regulation of the breast tumor suppressor gene EGR-1, and up-regulation of the immediate-early response genes FOS and JUN. Genistein Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens