Pub. Date : 2006 Jul
PMID : 16614167
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p53 suppression of arsenite-induced mitotic catastrophe is mediated by p21CIP1/WAF1. | arsenite | tumor protein p53 | Homo sapiens |
| 2 | Arsenite sensitivity correlates with deficient p53 pathways in multiple cell lines. | arsenite | tumor protein p53 | Homo sapiens |
| 3 | The role of p53 in preventing arsenite-induced mitotic arrest-associated apoptosis (MAAA), a form of mitotic catastrophe, was examined in TR9-7 cells, a model cell line with p53 exogenously regulated in a tetracycline-off expression system. | arsenite | tumor protein p53 | Homo sapiens |
| 4 | Cyclin B/CDC2(CDK1) stabilization and caspase-3 activation persisted in arsenite-treated p53- cells consistent with MAAA/mitotic catastrophe. | arsenite | tumor protein p53 | Homo sapiens |
| 5 | CDC2-Y15-P was transiently elevated in arsenite-treated p53+ cells but persisted in p53- cells. | arsenite | tumor protein p53 | Homo sapiens |
| 6 | Arsenite induced p53-S15-P and p21CIP1/WAF1 only in p53+ cells. | arsenite | tumor protein p53 | Homo sapiens |
| 7 | Arsenite induced p53-S15-P and p21CIP1/WAF1 only in p53+ cells. | arsenite | tumor protein p53 | Homo sapiens |