Title : Chaperoning of glucocorticoid receptors.

Pub. Date : 2006

PMID : 16610357






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 During GR-hsp90 heterocomplex assembly, the hydrophobic ligand-binding cleft is opened to access by steroid, and subsequent binding of steroid within the cleft triggers a transformation of the receptor such that it engages in more dynamic cycles of assembly/disassembly with hsp90 that are required for rapid dynein-dependent translocation to the nucleus. Steroids heat shock protein 90 alpha family class A member 1 Homo sapiens
2 During GR-hsp90 heterocomplex assembly, the hydrophobic ligand-binding cleft is opened to access by steroid, and subsequent binding of steroid within the cleft triggers a transformation of the receptor such that it engages in more dynamic cycles of assembly/disassembly with hsp90 that are required for rapid dynein-dependent translocation to the nucleus. Steroids heat shock protein 90 alpha family class A member 1 Homo sapiens
3 During GR-hsp90 heterocomplex assembly, the hydrophobic ligand-binding cleft is opened to access by steroid, and subsequent binding of steroid within the cleft triggers a transformation of the receptor such that it engages in more dynamic cycles of assembly/disassembly with hsp90 that are required for rapid dynein-dependent translocation to the nucleus. Steroids heat shock protein 90 alpha family class A member 1 Homo sapiens