Pub. Date : 2006 Jun
PMID : 16600694
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Aspirin and PPAR-alpha activators inhibit monocyte chemoattractant protein-1 expression induced by high glucose concentration in human endothelial cells. | Aspirin | C-C motif chemokine ligand 2 | Homo sapiens |
2 | The results showed that (i) aspirin, fenofibrate and clofibrate decrease significantly the MCP-1 expression and secretion in human endothelial cells; (ii) the high glucose up-regulated expression of MCP-1 in endothelial cells was significantly reduced by inhibitors of NF-kB and reactive oxygen species; (iii) all drugs notably decrease the level of the reactive oxygen species and activation of NF-kB and AP-1. | Aspirin | C-C motif chemokine ligand 2 | Homo sapiens |
3 | Together, the findings indicate that in endothelial cells aspirin and PPAR-alpha activators reduce the high glucose-increased expression of MCP-1 by a mechanism that includes the inhibition of reactive oxygen species, and decrease of AP-1 and NF-kB activation. | Aspirin | C-C motif chemokine ligand 2 | Homo sapiens |