Title : Halothane does not inhibit the functional coupling between the beta2-adrenergic receptor and the Galphas heterotrimeric G protein.

Pub. Date : 2006 Apr

PMID : 16571971






1 Functional Relationships(s)
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1 Halothane, even at concentrations of 1.5 mm (approximately 5.6 MAC), had no effect on basal Galphas nucleotide exchange in the absence of isoproterenol, whereas halothane inhibited isoproterenol-promoted Galphas nucleotide exchange in both the beta1-Galphas and beta2-Galphas expressing membranes. Isoproterenol potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens